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While it is marketed as an effective non-invasive fat reduction method, there are concerns about its safety and a lack of clinical evidence supporting its efficacy, especially when compared to more established alternatives like ultrasound-based treatments such as ULTRAcel Q+

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Notably, KIAA1199 (CEMIP) has been increasingly implicated in malignant progression across multiple carcinomas, including breast cancer, where its overexpression mediates invasive phenotypes [177,178,179,180,181]

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Retatrutide holds no MHRA or EMA marketing authorisation