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However, the considerable overlap of functions between these receptors is exemplified in breast cancer where it has been suggested that inhibition of both IGF-1R and IR may be required for effective antitumour response ( As well as the hypothalamic pituitary GH axis, IGF-1 secretion is controlled by autocrine/paracrine signals in peripheral tissues

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[10] In November 2024 the UK government announced legislation to require folic acid fortification in bread by the end of 2026