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2027 Capturing the impact of Facioscapulohumeral Muscular Dystrophy (FSHD) on Health-related Quality of Life (HRQoL): a systematic review of the reliability and validity of existing self-report instruments using COSMIN Jill Carlton 1 , Philip Powell 1 , S Frances 1 , Claire Williams 1 , Anthea Sutton 1 , Jonathan Street 1 , Channa Hewamadduma 1 , Jill Carlton 1 1 University of Sheffield, Sheffield, UK Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :2027 Aims Facioscapulohumeral muscular dystrophy (FSHD) is a rare genetic muscle wasting condition causing progressive weakness

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NICE guidance recommends continuing GLP-1 therapy for type 2 diabetes only if you achieve both an HbA1c reduction of at least 11 mmol/mol (1.0%) AND at least 3% weight loss after 6 months of treatment

A considerable portion of the preclinical literature involves the administration of semaglutide prior to or concurrently with disease induction, thereby reflecting a prevention or very early intervention paradigm rather than a treatment approach

For example, in the SURMOUNT-1 trial, nausea was reported by up to 28% of participants on the highest dose of tirzepatide