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Tirzepatide carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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It is crucial that rectal bleeding should always be evaluated with a thorough consultation and examination by an experienced general surgeon for an accurate diagnosis and treatment plan