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Mechanistically, the viral interleukin-6 (vIL-6) encoded by KSHV facilitates SIRT3-mediated deacetylation of SERBP1, preventing its binding to lipoyl transferase 2 (Lipt2) mRNA and protecting it from mRNA degradation-induced ferroptosis[146]

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The RER and energy expenditure (via the Weir equation) were calculated, while ambulatory activity was determined simultaneously

Interpretation should consider sex-specific reference ranges and assay variability