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The direct consequence of such a high dose is that the potency of the GLP-1 peptide component in the fusion had to be appropriately reduced to try minimising GLP-1-induced gastrointestinal side effects 18

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Activation and phosphorylation of signaling pathways such as Akt, and yes-associated protein 1-TEA domain transcription factor (YAP1-TEADs) also play a key role in fat differentiation

It could be a novel therapeutic agent for targeting colon cancer cells