If the molecular chaperone functions of HSP70 and HSP90 are impaired by genetic deletion, mutation, or pharmacological inhibition, cells may become less efficient at recognizing, refolding, or clearing misfolded proteins, thereby compromising proteostasis recovery (Rutledge et al., 2022
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Johnson City has a health-conscious, active community student athletes at ETSU, outdoor enthusiasts hitting the Appalachian Trail and Buffalo Mountain, healthcare workers managing their own recovery, and professionals who take their longevity seriously
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When skin biopsy #3 was obtained 6 months later, the proband demonstrated a visible reduction in the hCC deposition in biopsy #3 in comparison with the original skin biopsy