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Notably, administration of GEP44 resulted in an 80% reduction in food intake and a more profound loss of body weight than what could be achieved in response to treatment with several of the US Food and Drug Administration (FDA)-approved GLP-1RAs, including Ex-4 and liraglutide (LIRA)

More serious but less common adverse effects include: Pancreatitis : Patients should seek immediate medical attention if experiencing severe, persistent abdominal pain radiating to the back Gallbladder disease : Rapid weight loss can increase the risk of gallstones Hypoglycaemia : Particularly when used alongside other diabetes medications such as sulphonylureas or insulin Diabetic retinopathy complications : Rapid improvement in blood glucose control may temporarily worsen retinopathy in susceptible individuals Acute kidney injury : Usually in the context of dehydration from vomiting or diarrhoea Animal studies have shown an increased incidence of thyroid C-cell tumours with semaglutide, though the human relevance of this finding is unknown

Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle

Nat Commun 17 , 6178 (2026)

Real-world prevalence likely higher due to underreporting