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The effective semaglutide dose range in this paradigm (0.010.1 mg/kg for males, 0.030.1 mg/kg for females) is consistent with doses reported to reduce alcohol self-administration and intake (0.0003-0.01 mg/kg) in rodent and nonhuman primate models (0.0030.01 mg/kg
This weight reduction is particularly beneficial for non-diabetic individuals as well, helping to lower the risk of developing obesity-related conditions
Patients may also discuss FDA-approved alternatives with their healthcare provider to understand all available options
*J Orthop Res.* 21(6):976-983
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