Outside narrow, documented medical need, compounded versions of these drugs are no longer a lawful option, and FDA has logged hundreds of adverse event reports, some requiring hospitalization, tied to dosing errors from patients measuring their own doses out of compounded vials
It is often used in conjunction with lifestyle changes, such as diet and exercise, for weight loss
[16] Albracht-Schulte K, Kalupahana NS, Ramalingam L, et al
Reports of adverse events and dosing errors The FDA has received hundreds of adverse event reports linked to compounded versions of semaglutide and tirzepatide, including cases involving nausea, vomiting, abdominal pain, and other gastrointestinal symptoms
As an aside and earlier stage, Regeneron are interested in understanding obesity as a heterogeneous disease and, through the Regeneron Genetic Center, finding and developing novel genetic targets for obesity