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In neurons, excess intracellular zinc impairs mitochondrial function by dissipating the membrane potential, inhibiting ATP production, increasing ROS generation and permeability transition, disrupting calcium homeostasis and altering mitochondrial dynamics, contributing to neurodegenerative processes 153,154

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Tier 1: Full Documentation Standard Recommended Criteria met: Third-party HPLC purity report above 98%, mass spectrometry confirmation of molecular weight matched to the stated salt or free acid form, named ISO-accredited testing lab, batch number traceable between COA and product, refrigerated shipping, clear labeling of salt form, disclosed excipients

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