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Piccini S, et al
The polyol pathway, where excess glucose is converted to sorbitol and fructose by the enzyme aldose reductase, further exacerbates oxidative stress by depleting NADPH, a crucial cofactor for the regeneration of reduced glutathione (GSH) [180]
Less muscle mass would mean a slower rate of fat breakdown, causing it to accumulate in the body
The loading phase builds tissue concentration over 4 to 6 weeks, after which maintenance dosing preserves benefits with reduced frequency
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