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More physiologically relevant models such as 3D organoids, patient-derived xenografts, and genetically engineered mice are needed to better predict nanoplatform behavior

From there, recommendations are made clearly and practically.

Seth P, Wu X, Huang W, Leibach FH, Ganapathy V: Mutations in novel organic cation transporter (OCTN2), an organic cation/carnitine transporter, with differential effects on the organic cation transport function and the carnitine transport function

10.4103/jod.jod_78_22 26 EbiaiR.GoreJ.KaptenB

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