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Viana CE, Bortolotto VC, Araujo SM, Dahleh MMM, Machado FR, de Souza PA, et al

Data extraction included trial identification, publication year, participant demographics (age, BMI), detailed intervention characteristics (drug name, dosage, administration frequency, and duration), and all specified outcomes

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[7] [17] Gastrointestinal side effects including nausea, vomiting, diarrhea, constipation, and abdominal discomfort affect 2050% of patients, particularly during dose escalation periods

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