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Notably, elevated concentrations of the dimeric macrocycles (above 100 nM) decreased the observed level of Met phosphorylation and this bell-shaped titration response was also observed with elevated concentrations of hHGF (above 5 nM)

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Bayesian data assimilation has been suggested as a method to integrate patient data and address uncertainty in individualized treatments, a strategy that may also be applicable to peptide-based therapeutics

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