If you are already using GLP-1 agents for metabolic disease, the potential cognitive benefits provide an added rationale
Facts: Eating Sweets on GLP-1s Myth: You must completely cut out all sugar and dairy to lose weight on Ozempic
However, caution should be taken when interpreting these results due to short follow-up periods (i.e., 1.11.4 years [18,19,20]), the possibility of confounding bias caused by the inclusion of advanced T2D cases (i.e., requiring intensive insulin therapy [18]), uncertain liver effects (e.g., incident NAFLD) of active comparators (i.e., DPP4is [19, 20] and insulin [18]), lack of dose-response analysis, and limited generalizability to other ethnic populations
Further, for some patients initiation of tirzepatide may mean avoidance or delay of insulin therapy
Oral glucose tolerance evaluation across the combined study population indicated no adverse support for carbohydrate metabolism