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Mast cells are the body's immune sentinels, stationed at tissue boundaries like the skin, gut, and respiratory tract
A 2025 systematic review by Vasireddi and colleagues in HSS Journal screened 544 published papers and identified 36 meeting inclusion criteria 35 preclinical studies and only one human study: an uncontrolled, unblinded, retrospective case series of 12 patients receiving intra-articular BPC-157 for chronic knee pain, in which 7 of 12 (58%) reported self-described relief lasting more than 6 months, with no dose, effect size, or systematically collected adverse events published
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Targeting CAFs and ECM remodeling is a promising strategy (Fig
In addition, in the NAFLD rat model, Symbiter combined with Omega-3 therapy could significantly relieve liver steatosis and liver conversion lipid accumulation compared with probiotics alone (Kobyliak et al., 2017)
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