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In individuals with obesity, excess fat can lead to: Altered sex hormone levels : Increased aromatisation of androgens to oestrogens in adipose tissue, potentially affecting testosterone levels in both men and women [14] Insulin resistance : Which may impair endothelial function and reduce blood flow necessary for sexual arousal Elevated inflammatory markers : Chronic low-grade inflammation associated with obesity can negatively impact vascular and sexual health As weight decreases, these parameters often improve

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Figure 1 Figure 2 We also observed a significant decrease in waist circumference that was less than with tirzepatide at all maintenance doses, subcutaneous semaglutide 2.4 mg weekly, and oral semaglutide at a dose of 50 mg daily ( Of the 93 participants in our study, 11 patients (12%) discontinued treatment

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