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was also testified in HepG2 and HepaRG cells by culturing with 30 mM APAP (Choi et al., 2017)
While some studies have reported mixed findings, the strongest evidence does not support a clear link, and many reported associations are likely influenced by other lifestyle factors
Patients with Hepatic Impairment Sertraline clearance decreases substantially in hepatic impairment (the FDA label recommends halving the dose in mild impairment)
and inorganic cofactors , such as the metal ions Mg 2+ , Zn 2+ , Cu + , Mn 2+ and ironsulfur clusters
The role of glutathione-S-transferase in anti-cancer drug resistance
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