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In other words, in the first 1 to 3 months, GLP-1 patients may lose around 2 to 4 pounds per month while doses are titrated upward
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In the Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron produced mean body weight reductions of 7.5% (6 mg), 8.4% (12 mg), and 11.2% (36 mg) at 72 weeks, compared with 2.1% for placebo
