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The peak-to-trough ratio is most dramatic at lower doses
Head-to-head finding: Tirzepatide produced greater average weight loss than semaglutide in the SURMOUNT-5 study population
Stevens-Lapsley JE, Ye F, Liu M, et al
GLP-1 receptors are expressed not only in the pancreas and hypothalamus but also in cardiac myocytes (heart muscle cells) and along the vagus nerve, which controls heart rate through parasympathetic regulation
Gradual reductions often support better long-term outcomes and make it easier for the body to adjust to new eating patterns
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