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In a placebo-controlled clinical study, a 5% ALA cream delivered via a nanostructured lipid gel significantly reduced facial wrinkles and fine lines in adult volunteers after regular use

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Limitations of Ussing chamber measurements are the invasiveness because of the need for fresh intestinal tissue, and the lack of correlations between Ussing chamber data and other permeability assays raising the question of which aspects of the intestinal barrier can be assessed by this approach