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It is a condition in which the bodys response to a drug is lost after repeated exposure and requires higher doses to achieve the desired effects [5]
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The largest effect size of any non-surgical metabolic intervention in clinical trial history
Time- and dose-related improvements in insulin sensitivity were similar to the temporal patterns of body weight loss with retatrutide in both the MASLD cohort reported here and in the full cohort of people with obesity 13
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