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Melanocytic atypia is usually mild (although occasionally severe cytological atypia is present) and random, and consists of hyperchromatic nuclei and indistinct nucleoli

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Baio AR, Cai Z, Poulos RC, et al

Two types matter most in this discussion

However, practical outcomes matter more than mechanistic preferences, and tirzepatide superior clinical results suggest GIP agonism may be more effective overall