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Second, reductions in lean mass and neuroendocrine signals lower metabolic rate and overall EE [20]
Additionally, whilst the glucose-dependent mechanisms of both drugs mean hypoglycaemia risk remains low when used without insulin or sulphonylureas, combining them with other glucose-lowering agents could increase this risk
doi:10.2337/db11-1825 18
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The Basics of Compounding Definition: Compounding is the process of creating customized medications by combining, mixing, or altering pharmaceutical ingredients to meet specific patient needs
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