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In the Phase 2b VESPER-1 trial, dosing was given as 28 weekly doses to characterize dose-response, with the intent to transition to monthly dosing in Phase 3

All mice were sacrificed by anesthesia and bloodletting

If necessary to wash, wait for one hour before application

Month 3: Noticeable Changes (0.5 mg dose) Average weight loss: 4-6% cumulative (8-12 pounds for a 200-pound person) By month three, most people have been on 0.5 mg for at least four weeks

Although pharmacological therapies retain their efficacy, dietary supplements, including coenzyme Q10 (CoQ10), myo-inositol, melatonin, and vitamins, have emerged as a promising adjunct in infertility management due to their potential to mitigate oxidative stress, improve hormonal balance, and enhance reproductive capacity (Vitagliano et al., 2021)