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A standard weight-management titration reference (based on FDA-approved Wegovy protocol): Weeks 14: 0.25 mg once weekly Weeks 58: 0.5 mg once weekly Weeks 912: 1.0 mg once weekly Weeks 1316: 1.7 mg once weekly Week 17 onward: 2.4 mg once weekly (maintenance for obesity) For T2DM glycemic control, lower maintenance doses (0.52.0 mg weekly) are used per Ozempic labeling

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Discussion As diets high in protein are theoretically advantageous for patients with T2D and obesity due to their satiating properties compared with carbohydrate- and lipid-rich meals [25,26,27], specific amino acids selected for their appetite-reducing and GLP-1 stimulating effect may represent an approach for nutritionally based modulation of GLP-1 secretion

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