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Therefore, both temporal and spatial considerations of IGF-1R modulation will need to be considered in future trials with these drugs in order to clearly define the benefits and potential risks associated with this treatment, and guide development of strategies that allow for safe and effective long-term human use

The following section describes and summarizes these drugs in terms of the mechanisms by which they activate the GSH system (Table 3, Supplementary Table S3)

"Pfizer, Lilly to Resume Phase III Tanezumab Clinical Program"

Journal of Nutrition , 136 (6), 1636S1640S

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