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Common side effects may include transient flushing, injection-site reactions, water retention, or headache

Effects of GLP-1 agonists on mortality and arrhythmias in patients with type II diabetes

GLP-1 and dual-incretin agonists in metabolic-pathway research. Nat Rev Drug Discov

For example, USP19 promotes adipogenesis and exacerbates high-fat-diet-induced obesity and glucose intolerance in mice

Such mechanisms occur very rapidly, within 515 min upon receptor binding, indicating that the actions are not mediated by altered gene expression, but likely by phosphorylation of protein components of the secretory machinery 13