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Carland J, Mansfield R, Ryan R, Vandenberg R
Approximately 80-90% of gastrointestinal adverse events occurred during the dose-escalation period, and most resolved within 4-8 weeks
Injection site discomfort or swelling
Other studies in obese rats found similar lack of liraglutide induced increase in plasma insulin during OGTT [13, 35], suggesting that the lack of effect observed here might be explained by the animal model that is non-diabetic
A second paper, published in 1987, was a landmark: The tests showed that GLP-1 led to insulin secretion
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