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Deficiencies in B12 can also lead to elevations in the level of circulating homocysteine and elevated excretion of the oxidized dimer of homocysteine called homocystine
However, the effects are localized and may not influence systemic glutathione levels
In addition, a low level of GPx3 is an independent predictive marker of the local recurrence of early-stage invasive breast cancer in patients undergoing breast-conserving surgery and radiotherapy, regardless of the patients clinicopathological parameters [104]
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