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3 BDNF Hippocampus mRNA Increase in BDNF exon III mRNA in the hippocampus after a single dose (Dolotov et al., 2006) 7 AA Heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro sequence ACTH(4-10) + stabilizing tripeptide Pro-Gly-Pro 813.93 Da Molecular Weight Formula CHNOS CAS 80714-61-0 | Purity 98% HPLC DA/5-HT Neurotransmitters Activation of the brain's dopaminergic and serotonergic systems (Eremin et al., 2005) Russia 2011 Approved List of Vital and Essential Medicines of the Russian Federation (Stroke, cognition) Mechanism of Action Neurotrophin & Neuroprotection Upregulation of BDNF/trkB, dopaminergic/serotonergic activation and anti-ischemic neuroprotection Primary Route BDNF/trkB Upregulation of Neurotrophic Factor Semax rapidly increases BDNF levels (1.4x protein, 3x exon III mRNA) and phosphorylation of its receptor trkB (1.6x) in the hippocampus after a single administration of 50 g/kg

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On the other hand, glutathione depletion was shown to inhibit adipogenesis as the result of lowering cell proliferation during the initial mitotic clonal expansion of the adipocyte differentiation process [110]

Blood glucose was measured as described previously, and plasma acetaminophen levels were measured by LC/MS method at the same time points

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