a , Thermal stability (Tm) comparison of GLP-1R wild-type and StaR (containing the following point mutations: T207E, Q211A, D215R, L232F, G295A, T298A, C329A, P358A, G361A, H363V and V405A)
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Consistent with the transcriptomic findings, proteomic analysis of liver from Gclc KO mice revealed that most significantly elevated proteins in Gclc KO liver were encoded by NRF2 target genes, including the canonical NRF2 target NQO1 (NAD(P)H Quinone Dehydrogenase 1) (Fig