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M1 macrophages, induced by Toll-like receptor ligands (e.g., LPS) or Th1 cytokines such as TNF-, IFN-, and colony-stimulating factor 2 (CSF2), are characterized by surface expression of TLR2, TLR4, CD80, and CD86 (84)

Batch effects were corrected using Harmony, with group1 as the integration variable

For example, many studies observed mitochondrial damage in postmortem brain samples and mouse models of AD, PD and ALS 2,3

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