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Several phase 3 randomized controlled trials, which excluded individuals with a history of bariatric surgery, proved superior weight loss with semaglutide 2.4mg compared to placebo in individuals with obesity or metabolically complicated overweight: 12.4% in general (33), 11.1% in East Asian populations (34), 6.2% in individuals with type 2 diabetes (35), and 13.3% in the setting of intensive lifestyle modification (36)
Challenges and Limitations Despite their benefits, dual agonists may not address all metabolic abnormalities, particularly in patients with complex pathophysiology involving multiple dysregulated pathways
GLP-1 receptors sit on pancreatic beta cells, in the brainstem, hypothalamus, vagal afferents, and gut
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