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Several factors cause perimenopause weight gain

Up to 30 percent of people with psoriasis go on to develop psoriatic arthritis, an inflammatory joint disease that can cause pain, swelling, and long-term joint damage

Back Althage, MC, Ford, EL, Wang, S, et al (27 June 2008) 'Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet', Journal of Biological Chemistry , 283/26, 18365-76

There was, however, a challenge: the half-life of GLP-1 in plasma was only 1-2 minutes