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Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)
"Thymosin beta4: a multi-functional regenerative peptide." Expert Opin Biol Ther
It does not establish that cagrilintides longer half-life means a better outcome half-life is pharmacokinetics, not efficacy
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