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When MTHFR activity is reduced, 5-MTHF production falls methionine regeneration is impaired homocysteine accumulates folate is increasingly sequestered as 5,10-MTHF THF availability for nucleotide synthesis falls

Hussein Tawbi of MD Anderson Cancer Center argued the therapy should be available to patients until the Phase 3 trial reads out

Injectable GHK-Cu should only be dosed by a licensed medical professional