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PT-141 was patented and pushed into clinical development by Palatin in the early 2000s

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It is characterized by recurrent abdominal pain associated with altered bowel habits, including diarrhea (IBS-D), constipation (IBS-C), or mixed patterns (IBS-M)

Studies consistently show that Ipamorelin maintains the natural pulsatile pattern of GH secretion rather than causing unnatural sustained elevation, which is considered beneficial for maintaining normal feedback regulation (PMID: 9849822)

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