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In colorectal cancer, SCFAs, especially butyrate, function as anti-inflammatory metabolites and histone deacetylate (HDAC) inhibitors, resulting in the suppression of cancer progression (72)

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The phase 1 data described in the same paper indicated that the molecule reached steady-state concentrations consistent with an extended dosing interval and was associated with dose-dependent changes in pharmacodynamic markers of incretin receptor engagement

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