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Improved Fertility: These medications have improved fertility in both male and female patients

Furthermore, LCs ability to regulate fatty acid oxidation affects systemic inflammation and immunological responses, as metabolites such as SCFAs can influence immune cell activity and gut barrier integrity [9, 4447]

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Two symbols (**, ##, or $$) denote significant difference below 0.005, three symbols (***, ###, or $$$) denote significant below 0.0001

For people in this situation, the calorie deficit needs to be smaller, around 300-400 calories, with a greater emphasis on exercise to create the remaining deficit through activity rather than food restriction