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People taking lower doses of Qsymia lost an average of ~8% of their body weight over a year, and those on higher doses lost as much as 10%

Safety, Tolerability, and Efficacy of Monotherapy and Combination Regimens in Adults With Nonalcoholic Steatohepatitis (NASH)

Other studies have also shown that NPY is able to hydrolyze phosphoric inositol on cell membranes into an inositol trisphosphate (IP3) signal substance, which can promote the release of calcium ions and increase the concentration of extracellular calcium ions (82)

The trial involved 203 obese individuals who were randomly assigned to receive Tesofensine at doses of 0.25 mg, 0.5 mg, 1.0 mg, or a placebo daily for 24 weeks