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The GH-IGF1 axis keeps showing up in peptide medicine because it links visceral fat, recovery, and lean mass
Rather than stopping entirely and risking the weight regain documented in the STEP 1 extension trial (Wilding et al., Diabetes Obes Metab, 2022), where participants regained two-thirds of lost weight within one year of stopping, a microdose may provide enough GLP-1 receptor activation to maintain the appetite set-point shift
Physical Repair Beyond the Gym: In addition to performance and recovery, IGF-1 LR3 is also beneficial for general physical repair
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The researchers then looked at whether women were diagnosed with a new breast cancer in two different cohorts: the full group of 111,646 women and a smaller cohort of 30,528 women, including one-to-one controls for each of the 15,264 GLP-1 cases, matched across age, race, ethnicity, BMI, breast density, and diabetes status to limit bias and potential confounding
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