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Active targeting involves the attachment of ligands to the surface of nano systems (165, 166) to enhance their interaction with proteins that are consistently expressed at the blood-brain barrier, including the insulin receptor, transferrin (Tfr) (167), and low-density lipoprotein receptor (168, 169)

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Since IR is known to influence AD pathology, the ability of these hepatokines to impact both conditions suggests a multifaceted therapeutic potential for addressing metabolic and neurological dysfunctions

Lets rewind to high school science class for a minute