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Subgroup analysis The results from subgroup analyses are shown in ESM Tables 27
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Over 75% of health plans and over 50% of employers are moderately or very concerned about off-label use of GLP-1s approved for type 2 diabetes, but awareness of how much current spend is off-label is notably lower: nearly half of employers and a quarter of health plans are unsure
Additionally, the upregulation of ribosomal proteins enhances protein synthesis, and glycolytic enzyme overexpression boosts energy production, collectively contributing to the parasites survival and resistance ( A comparative overview of resistance mechanisms across major antileishmanial drugs is provided in Table 3, highlighting recurrent themes such as transporter upregulation, metabolic adaptations, and genetic mutations
