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The risk of photolysis Even though B12 is very stable when dry, it is also extremely light-sensitive in liquid form
Reconstituted solutions are generally kept refrigerated and protected from light, while the unopened lyophilized powder is stored frozen for longer-term stability
I found this really intriguing because before I was diagnosed with PA and treated with B12 injections, I was heading down the path of gastroparesis
But the study authors named it explicitly as an off-target activity they are working to engineer out, and even speculated that some of the glucose-tolerance benefit might come from it
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