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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of injectable (and one oral) medicines used to manage type 2 diabetes mellitus in adults
Updated May 5, 2026
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The mechanism involves reduced availability of the precursor amino acids glycine and cysteine in older adults, which directly limits how much glutathione the body can synthesize
Using preclinical models of this condition, it was shown that in vitro GLP-1RA liraglutide enhances the nuclear translocation of Nrf2 factor, reducing damage to cells, modulates the MAPK/NF-kB signaling pathway, decreasing the expression of inflammatory factors and proteins, and in vivo protects cognitive dysfunction under conditions of periodic hypoxia in mice
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