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Effects of tamoxifen-loaded solid lipid nanoparticles on the estrogen receptor- (ER-) and vascular endothelial growth factor-A (VEGF-A) genes expression in the endometrial tissue of ovariectomized female Sprague-Dawley rats

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185 Estrogen taken orally undergoes transformation in the liver prior to reaching the systemic bloodstream, a phenomenon known as first pass. The by-products of estrogen metabolism in the liver have more negative side effects, particularly cardiovascular effects, than estrogen

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