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The major de novo pathway is diagrammed in the Figure below
Gulewitsch, W
Metzendorf NG, Godec A, Petrovic A et al (2025) Somatostatin therapy, neprilysin activation, and amyloid beta reduction: a novel approach for Alzheimers treatment
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For example, certain probiotics (e.g., lactobacilli ) reportedly activate the NRF2 pathway via metabolic routes [148], while some pathogens (e.g., Salmonella , Helicobacter pylori ) activate NOX1, upregulate ROS, and induce inflammation [149]
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