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Weight-loss medications in the 20th century proved to be equally dangerous: dinitrophenol, a mitochondrial proton pump uncoupler, was remarkably effective at shedding pounds but led to nerve malfunction and arrhythmia induced fatalities

Additionally, non-oxidative pathways regulated by fatty acid ethyl ester synthase and phospholipase D are involved in the generation of fatty acid ethyl esters and phosphatidylethanol (Park et al., 2022b)